Since 1991 the John Wayne Cancer Institute (JWCI) has had an affiliation with Providence Saint John’s Health Center. The John Wayne name was committed to this endeavor by the Wayne Family, for leading-edge cancer research and education, in memory of their father who died of stomach cancer in 1979. 

Many of the physicians and surgeons who are treating and caring for patients in the John Wayne Cancer Clinics at Providence Saint John’s Health Center are also faculty, adjunct faculty and physicians in a fellowship program affiliated with the John Wayne Cancer Institute. The John Wayne Cancer Institute is a cancer research organization dedicated to the understanding and curing of cancer in order to eliminate patient suffering worldwide.

For more than 25 years, Providence Saint John's Health Center and the John Wayne Cancer Institute are at the vanguard of breakthrough cancer research, internationally prominent medical expertise and leading-edge treatments.  Providence Saint John's and JWCI oncology team members have discovered some of the world's leading cancer breakthroughs.

Sentinel node biopsy

The late Donald L. Morton, M.D., Chief of the Melanoma Program at John Wayne Cancer Institute at Providence Saint John’s Health Center originated the sentinel lymph node technique for staging melanoma.  This revolutionary diagnostic technique helps surgeons determine if a tumor has spread to nearby lymph nodes rather than simply removing them; a practice that can cause permanent side effects.

The technique involves injecting a blue dye and radioactive substance into the lymphatic system near the tumor. As the dye is absorbed, it identifies the sentinel node so that it can be excised and analyzed for evidence of cancer spread. If cancer has not invaded the sentinel node, the surgeon may elect to leave the other healthy lymph nodes in place. The sentinel node technique has become the international medical standard for melanoma surgery, and is being adapted to many other cancers. Notably, Dr. Morton was a recipient of the Jacobson Innovation Award of the American College of Surgeons.

Anton J. Bilchik, M.D., Chief of Medicine, adapted the sentinel node technique for patients with colon cancer.

Minimally invasive brain surgery

Neurosurgeons at Providence Saint John’s Health Center are internationally recognized as pioneers in minimally invasive brain surgery.  By developing and improving “kinder, gentler” brain surgery procedures and brain-mapping techniques, they minimize the need for complex, risky craniotomies while sparing the patient’s sensitive brain tissue. 

Medical Director of the Brain Tumor Center Daniel Kelly, M.D., has performed more than 1,400 minimally invasive procedures from a number of access points.  Dr. Kelly, an international leader in minimally invasive brain surgery, has extensive experience in removing brain tumors through the nostrils as well as through keyhole incisions above the eyebrow.  Recently, efforts have focused on developing a surgical tube (brain cannula) combined with detailed fiber tract mapping of the brain (tractography), to optimize the safe endoscopic removal of deeply situated brain tumors.

Novel blood biomarker assays

David Hoon, PhD, Director, Translational Molecular Medicine Department and his team at John Wayne Cancer Institute at Providence Saint John’s Health Center have developed novel blood biomarker assays to help research melanoma, lung and breast cancer, as well as other cancers.  The goal of their research is to find biomarkers with potential clinical utility, and to speed the identification of new drug strategies and treatments. Dr. Hoon’s team has made great strides in defining specific classes of cancer, analyzing tumor-related genomic changes, and screening FDA-approved and targeted drugs. 

Molecular Diagnostic Techniques

A pioneering study led by Dr. Hoon and his colleagues found that highly sensitive molecular diagnostic techniques can effectively “upstage” early-stage colorectal cancer patients who would normally be declared to be cancer-free when evaluated using conventional tests.  The findings could lead to better, more sensitive cancer detection methods.  The study may also help scientists develop more consistent ways to identify patients who would benefit the most from adjuvant therapy after surgery for colorectal cancer.

Clinical trials

To view a list of clinical trials associated with the John Wayne Cancer Institute and Providence Saint John’s Health Center, please visit www.clinicaltrials.gov.